Explain the appropriate drug therapy for a patient who presents with MDD and a history of alcohol abuse

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 Short Answer Assessment

Explain the appropriate drug therapy for a patient who presents with MDD and a history of alcohol abuse. Which drugs are contraindicated if any, and why? Be specific. What is the timeframe that the patient should see a resolution of symptoms?

The appropriate drug therapy for a client presenting an MMD disorder and PMH of drug dependence would be an integrated treatment of Sertraline 25mg plus naltrexone 50mg orally daily. The client’s symptoms would reduce significantly after four weeks. Sertraline plus naltrexone combination have been proven to produce higher alcohol abstinence rates, longer days before relapse, and complete reduction of depressive disorder without serious adverse events (Pettinati et al., 2010). It is contraindicated that clients taking Selective serotonin reuptake inhibitors (SSRI) such as Sertraline be monitored during the early stages of medication for emergent suicide ideation, agitation, behavioral changes, or manic episodes as indications of poor response that warrants medication adjustments (The Anxiety and Depression Association of America, 2020).(Explain the appropriate drug therapy for a patient who presents with MDD) As you continue, premiumacademicaffiates.com has the top and most qualified writers to help with any of your assignments. All you need to do is place an order with us.

List 4 predictors of late-onset generalized anxiety disorder.

Predictors of late-onset GAD include (Zhang et al., 2015):

1. Gender, particularly being female
2. Chronic physical and mental health disorders
3. Loss of a parent through death/divorce/separation
4. Reduced affective childhood support

List 4 potential neurobiology causes of psychotic major depression.

According to Aan het Rot et al. (2009), the major neurobiological causes of psychotic MDD relate to the serotonin and dopamine system changes. This includes a complex interaction between serotonin dysfunction, stress hypersensitivity, and dopamine dysfunction. These factors include:

1. Psychosocial adversity in childhood
2. Dysfunctional regulation of the hypothalamic-pituitary-adrenal axis
3. Abnormal brain activation patterns
4. Neurobiological abnormalities underlying brain atrophy

An episode of major depression is defined as a period lasting at least two weeks. List at least five symptoms required for the episode to occur. Be specific.

According to the American Psychiatric Association, symptoms required for an episode of MDD to occur include (APA, 2013):

1. Depressed mood for the greater part of the day and almost every day(Explain the appropriate drug therapy for a patient who presents with MDD)
2. Minimal pleasure/interest in carrying out almost every daily routine every day
3. Substantial weight change, decrease/increase in appetite when not dieting for a significant portion of the day and almost every day
4. Fatigue/energy loss for the greater part of the day and almost every day
5. Minimal thinking/concentrating ability or inappropriate guilt for the greater part of the day and almost every day

As you continue, premiumacademicaffiates.com has the top and most qualified writers to help with any of your assignments. All you need to do is place an order with us. (Explain the appropriate drug therapy for a patient who presents with MDD and a history of alcohol abuse)

List 3 classes of drugs, with a corresponding example for each class, that precipitate insomnia. Be specific.

There many classes of drugs recommended for the treatment of insomnia. Three of these classes include (Lie et al., 2015):

1. Sedative-Hypnotics for example, Zolpidem
2. Antidepressants, for example, Doxepin
3. Dual Orexin Receptor Antagonists, for example, Suvorexant.

References Aan Het Rot, M., Mathew, S. J., & Charney, D. S. (2009). Neurobiological mechanisms in major depressive disorder. Cmaj, 180(3), 305-313. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630359/ American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (5 ends). American Psychiatric Association, 21. Retrieved 23 March 2021, from. https://www.psycom.net/depression-definition-dsm-5-diagnostic-criteria/ Lie, J. D., Tu, K. N., Shen, D. D., & Wong, B. M. (2015). Pharmacological treatment of insomnia. Pharmacy and Therapeutics, 40(11), 759. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634348/(Explain the appropriate drug therapy for a patient who presents with MDD) Pettinati, H. M., Oslin, D. W., Kampman, K. M., Dundon, W. D., Xie, H., Gallis, T. L., … & O’Brien, C. P. (2010). A double-blind, placebo-controlled trial combining Sertraline and naltrexone for treating co-occurring depression and alcohol dependence. American Journal of Psychiatry, 167(6), 668-675. https://doi.10.1176/appi.ajp.2009.08060852 The Anxiety and Depression Association of America. (2020). Available at: https://adaa.org/resources-professionals/practice-guidelines-mdd#Contraindicated%20Treatment [Accessed 23 March 2021](Explain the appropriate drug therapy for a patient who presents with MDD) Zhang, X., Norton, J., Carriere, I., Ritchie, K., Chaudieu, I., & Ancelin, M. L. (2015). Risk factors for a late-onset generalized anxiety disorder: results from a 12-year prospective cohort (The ESPRIT study). Translational psychiatry, 5(3), e536-e536. https://doi.10.1038/tp.2015.31 As you continue, premiumacademicaffiates.com has the top and most qualified writers to help with any of your assignments. All you need to do is place an order with us. (Explain the appropriate drug therapy for a patient who presents with MDD)

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